Synonyms:
cis-Diaminodichloroplatinum(II)
, cis-Diamminedichloroplatinum (II)
, cis-Diamineplatinum(II) dichloride
, Platinol
, cis-Dichlorodiammine platinum(II)
, Cisplatin
400-040-M250
400-040-M050
89150-634EA
171
USD
InStock
89150-634
89150-632
cis-Platin ≥98%
cis-Platin
Antitumor agent
- Formulation: Off-white to orange powder.
- Endotoxin-content: ≤1.0EU/mg
A potent platinum-based antineoplastic drug. Its mode of action invovles formation of inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I. Cisplatin synergizes with a variety of anticancer agents. Tumor cells rapidly develop resistance to cisplatin and numerous agents are available to block or reverse resistance.