Synonyms:
Rock inhibitor y-27632
, (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride
, trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
, Y-27632 2HCl
Packaged under inert gas.
688001-500UG
80512-706EA
229.81
USD
InStock
80512-706
Y-27632 dihydrochloride, InSolution™, Calbiochem®
Y-27632 dihydrochloride
A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688000) in H₂O.
A highly potent, cell-permeable, selective inhibitor of Rho-associated protein kinase (Ki = 140 nM for p160ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 mM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contractions (IC50 = 700 nM for phenylephrine-induced contractions in aortic strips).