Synonyms:
2-Aminoethyl diphenylborinate
, 2-((Diphenylboryl)oxy)ethanamine
400-045-M100
89150-650EA
50.2
USD
InStock
89150-650
Diphenylboric acid-2-aminoethyl ester (2-APB) ≥98% (by HPLC)
Diphenylboric acid 2-aminoethyl ester (2-APB)
Cell permeable modulator of Ins(1,4,5)-P3-induced Ca2+ release. A prototype drug for a group of structurally related calcium channel blockers in human platelets. Has been shown, in the absence of other stimuli, to activate TRPV1, V2 and V3, but not TRPV4, V5 and V6 expressed in HEK 293 cells. Potentiates the effect of capsaicin, protons and heat on TRPV1. It was originally introduced as an IP3 receptor blocker and subsequently as an inhibitor of store-operated Ca2+ entry (75µM).
White to off-white crystalline solid.
Soluble in DMSO (20mg/ml), dimethyl formamide (20mg/ml) or 100% ethanol (5mg/ml); slightly soluble in PBS, pH 7.2 (50μg/ml).