Synonyms:
Neomycin B sulphate
, Neomycin B sulfate
J61499-22
J61499-14
J61499-22
J61499-14
AAJ61499-22EA
138.93
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AAJ61499-22
AAJ61499-14
CAAAJ61499-14
CAAAJ61499-22
Neomycin trisulfate salt hydrate
Neomycin trisulfate salt hydrate
An antibiotic. Acts as an inhibitor of protein biosynthesis
Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria.
Neomycin sulfate inhibits Phospholipase C via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.