Synonyms:
TPA
, 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
J63916-LB0
J63916-MCR
J63916-MA
J63916-MA
J63916-MB
J63916-MB
AAJ63916-LB0EA
277.1
USD
InStock
AAJ63916-LB0
AAJ63916-MA
AAJ63916-MCR
AAJ63916-MB
CAAAJ63916-MA
CAAAJ63916-MB
Phorbol-12-myristate-13-acetate 95%
Phorbol-12-myristate-13-acetate
Activates protein kinase C and promotes skin tumors in mice.
PMA activates Ca2+ - ATPase and potentiates forskolin-induced cAMP formation. Used to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Caution: Light sensitive. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.