Synonyms:
1alpha,25-Dihydroxyvitamin D3
, (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-Hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
, 1,25-Dihydroxycholecalciferol
BML-DM200-0050
BML-DM200-1000
89157-378EA
2710
USD
InStock
89157-378
89157-376
Calcitriol ≥99% (by HPLC)
Calcitriol
Ultra-high purity
1α,25-Dihydroxyvitamin D3 is the active hormonal form of vitamin D. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, HL-60 cells. It is a central regulator of bone and calcium homeostasis. A polymorphism in the vitamin D receptor gene has been linked to a genetic predisposition to osteoporosis. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, keratinocytes, HL-60 cells vascular smooth muscle cells and bone marrow macrophage precursors. It can activate signal transduction pathways that include hydrolysis of phosphatidylcholine and formation of diacylglycerol in chick myoblasts, and activation of Raf kinase in rat hepatic primary cells and 3T3 fibroblasts. It regulates c-myc protooncogene transcription, interleukin-8 expression, induction of cyclooxygenase, and directly activates protein kinase C at physiological concentrations (EC50=16 nM). Up-regulates RANKL level and down-regulates OPG level.