Synonyms:
2-(((4-Phenoxyphenyl)sulphonyl)methyl)thiirane
, 2-(((4-Phenoxyphenyl)sulfonyl)methyl)thiirane
BML-EI325-0001
BML-EI325-0005
89158-078EA
347.91
USD
InStock
89158-078
89158-076
SB-3CT ≥98% (by TLC)
SB-3CT
Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.
White solid.
Soluble in DMSO (at least 30mM) or 100% ethanol.