Synonyms:
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
, all-trans-Retinoic acid
, Vitamin A acid
, ATRA
, Tretinoin
BML-GR100-0500
BML-GR100-5000
89158-734EA
477
USD
InStock
89158-734
89158-732
Retinoic acid all trans ≥95%, yellow solid
Retinoic acid
Retinoic acid receptor ligand
Retinoic acid is the active metabolite of vitamin A. It is a potent modulator of growth and differentiation exerting its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. All trans retinoic acid binds to RAR α, β and γ subtypes with Kd values of 0.2, 0.4 and 0.2 nM respectively. RARs function as ligand-dependent transcription factors. Retinoic Acid also promotes the differentiation of mouse embryonic stem cells into adipocytes, neurons and glia in vitro. It guides development of the posterior part of the embryo.
Soluble in DMSO (25 mg/ml) or ethanol (10 mg/ml).