Synonyms:
TPA
, 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
AG-CN2-0010-M025
AG-CN2-0010-M010
AG-CN2-0010-M001
AG-CN2-0010-M005
102515-698EA
470.77
USD
InStock
102515-698
102515-696
102515-694
102515-692
Phorbol 12-myristate 13-acetate ≥98% (by HPLC)
Phorbol-12-myristate-13-acetate
Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.