Synonyms:
Arabinosylcytosine hydrochloride
, Cytarabine HCl
, 4-Amino-1-((2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one hydrochloride
, 1-(β-D-Arabinofuranosyl)cytosine HCl
02100071.5
0210007101
02100071.1
IC10007101EA
388.28
USD
InStock
IC10007101
IC100071.1
IC100071.5
Cytosine-β-D-arabinofuranoside hydrochloride, Powder
Cytosine-beta-D-arabinofuranoside hydrochloride
Cytosine β-D-arabinofuranoside hydrochloride is an anti-leukemic agent. It results in DNA fragmentation and inhibition of replication. In addition this compound does not have any effects on RNA synthesis. Cytosine β-D-arabinofuranoside hydrochloride can function as a ligand which shows strong affinity and selectivity for the Translocator protein (TSPO). Studies suggest that Cytosine β-D-arabinofuranoside hydrochloride can down-regulate deoxycytidine kinase in acute myeloid leukemia murine cell lines which inhibits the phosphorylation of several deoxyribonucleosides. Furthermore, Cytosine β-D-arabinofuranoside hydrochloride can be inhibited in myeloid leukemic cells via suppression of ENT1 promoter activity, responsible for transporting Cytosine β-D-arabinofuranoside into the cell.
Cytosine β-D-arabinofuranoside hydrochloride is a selective inhibitor of DNA synthesis that does not affect RNA synthesis in mammalian cells. It is used as an antineoplastic and antiviral agent.
Soluble in water (50 mg/mL - clear, colorless solution).
Ara-C an anti-leukemia agent is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. It does not inhibit RNA synthesis.