Synonyms:
2-IT
, 2-IT HCl
, 2-Iminothiolane hydrochloride
, 2-Thiolanimine hydrochloride
0215131980
0215131990
IC15131980EA
69.83
USD
InStock
IC15131980
IC15131990
2-Iminothiolane hydrochloride (Traut's Reagent) (synthetic), powder
2-Iminothiolane hydrochloride (Traut's Reagent)
2-Iminiothiolane hydrochloride is a thiolating reagent that is used in the preparation of disulfide and thioether linked conjugates, such as for protein crosslinking.
It has a preference for primary amino groups and reacts at pH 7-10 to give amidine compounds which contain free sulhydryl groups. The amidine linkage preserves the original primary amine positive charge. A mechanistic study of the reaction of 2-iminothiolane with amino groups in peptides and proteins has been published. 2-Iminothiolane has also been utilized to prepare glycoprotein-antibody conjugates, streptavidin-antibody conjugates, and avidin-protein nanoparticle conjugates.
Soluble in water (100 mg/mL) and methanol.