0215961101
IC15961101EA
220.81
USD
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IC15961101
Ionomycin ≥90%
Ionomycin
Ionomycin is a highly selective calcium ionophore and a polyether antibiotic produced by Streptomyces conglobatus.
Ionomycin is a useful tool for increasing intracellular Ca2+ concentration
Ionomycin is a Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+. It induces apoptotic degeneration of embryonic cortical neurons, induces central demyelination and inhibits adrenal bovine TREK-1 channels.
It is also used to equilibrate intracellular and extracellular calcium ion levels for in situ calibrations of fluorescent indicators. It is used to study the effects of calcium flux on endoplasmic reticulum (ER) stress, mitochodrial stress and intrinsic apoptosis mechanisms. It is also used to stimulate the intracellular production of the cytokines, interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA.
Soluble in DMSO (25 mg/mL) and acetonitrile (10 mg/mL)