Synonyms:
NMD Inhibitor II
, Garamycin
, Gentiomycin C
, Gentamicin sulfate salt
, Gentamicin sulphate salt
02190057.2
0219005701
0219005725
0219005705
0219005710
IC19005705EA
513.24
USD
InStock
IC19005705
IC190057.2
IC19005701
IC19005725
IC19005710
Gentamicin sulfate USP
Gentamicin sulphate
Gentamicin sulfate is an aminoglycoside antibiotic complex produced by fermentation of Micromonospora purpurea or M
- USP Grade
- Presentation: White Powder
- H2O: soluble 50 mg/mL
- Loss on drying: ≤18.0 %
- Optical rotation: +107° to +121° (10 mg/mL, water)
- pH: 3.5 - 5.5 (1 in 25, in water)
Gentamicin sulfate is used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms.
Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface. Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria.
echinospora. It is a mixture of 3 major components designated as C1, C1a, and C2. Gentamicin is used as the sulfate salt. Each component consists of five basic nitrogens and requires five equivalents of sulfuric acid per mole of gentamicin base.
White
Soluble in Water (50 mg/mL)