Synonyms:
SR1
, 4-(2-((2-(Benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol
, 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol hydrochloride
AB142174-5MG
AB142174-1MG
10191-214EA
689.5
USD
InStock
10191-214
10191-212
StemRegenin 1 ≥98% (by HPLC)
StemRegenin 1
A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.