178494-10MG
178494-10MG
80603-046EA
195.1
USD
InStock
CA80603-046
80603-046
Ns3694, Calbiochem®
Ns3694
The Apoptosis Inhibitor II, NS3694, controls the biological activity of Apoptosis
- CAS number: 426834-38-0
- Form: White solid
- Hill Formula: C₁₅H₁₀ClF₃N₂O₃
- Chemical formula: C₁₅H₁₀ClF₃N₂O₃
- Primary Target: Apoptosome complex formation
- Primary Target IC50: 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
- Purity: ≥95% by HPLC
- Storage: +2°C to +8°C
A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
This small molecule/inhibitor is primarily used for Cancer applications.