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Phorbol-12-myristate-13-acetate ≥99%, colorless material
Phorbol-12-myristate-13-acetate
PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. Potent tumor promoter; activates protein kinase C in vivo and in vitro. Store at -20 °C. Protect from light.
Purity: >99%
Presentation: Colorless Material
Very soluble in methanol; soluble in DMSO (25 mg/mL), chloroform (25 mg/mL), ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.