Synonyms:
5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
681535-1MG
681535-5MG
681535-5MG
681535-1MG
EM681535-1MGEA
205.13
USD
InStock
CA80016-612
EM681535-1MG
EM681535-5MG
CA80016-610
Withaferin A (from Withania somnifera), Calbiochem®
Withaferin A
Angiogenesis inhibitor.
- White solid in form
- Purity: ≥94% (by HPLC)
A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Isolated from Withania somnifera.
Packaging: Packaged under inert gas.