Synonyms:
KMUH
22111
22111
PI22111EA
489.08
USD
InStock
PI22111
CAPI22111
KMUH (N-(κ-maleimidoundecanoic acid) hydrazide trifluoroacetic acid salt), Pierce™
KMUH (N-(κ-maleimidoundecanoic acid) hydrazide trifluoroacetic acid salt)
Thermo Scientific Pierce KMUH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).
- Reactive groups: maleimide and hydrazide
- Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups
- Long (19.0A), sulfhydryl-to-aldehyde crosslinker with simple aliphatic spacer arm (noncleavable)
- Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
- Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
- Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
- Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups
Sufficient For: 122mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use 50mg
Caution: For Research Use Only. Not for use in diagnostic procedures.