Synonyms:
5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
, 4',5,7-Trihydroxyisoflavone
, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
, 4',6'-Dihydroxy-3-(4-hydroxyphenyl)benzo(e)oxacyclohex-2-en-4-on
345834-50MG
345834-20MG
345834-50MG
345834-20MG
80051-868EA
180.3
USD
InStock
80051-868
CA80051-868
80051-870
CA80051-870
Genistein, Sigma-Aldrich®
Genistein
Inhibits protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50=2.6µM)
The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50>350µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro.