Synonyms:
17-(Allylamino)-17-demethoxygeldanamycin
, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
A20045-0.0005
A20045-0.005
A20045-0.001
76344-646EA
89.67
USD
InStock
76344-646
77510-162
76344-648
17-AAG
17-AAG
17-AAG (17-Allylamino-17-demethoxygeldanamycin) is a synthetic derivative of geldanamycin. Like geldanamycin, 17-AAG is recognised for its role as an inhibitor of heat shock protein 90 (Hsp90), a molecular chaperone involved in protein folding and stabilisation.
It is often used as a tool to study Hsp90-dependent processes. By inhibiting Hsp90, 17-AAG impacts the stability and function of various client proteins, many of which are involved in critical cellular processes, including signal transduction and cell cycle regulation. Similar to geldanamycin, 17-AAG is particularly relevant in cancer research, as Hsp90 is often crucial for the stability of oncoproteins. Researchers use 17-AAG to explore the molecular mechanisms of Hsp90 inhibition, with potential applications in understanding cancer biology and developing therapeutic strategies.
Caution: Research or further manufacturing use only, not for food or drug use.