Synonyms:
17-(Allylamino)-17-demethoxygeldanamycin
, (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NB110-81558
102125-504EA
352.43
USD
InStock
102125-504
17-AAG (synthetic)
17-AAG
Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG. 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin and UCN-01 (400 nM 17-AAG, U937 cells).
- Soluble in DMSO (20mg/mL) or mehtanol (10mg/mL)
- Purple solid
Caution: This product is for research use only and is not approved for use in humans or in clinical diagnosis.