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Masterflex Pumps Ensure Precise Repeatable and Flexible Pharmaceutical Production
Gregg E. Johnson, Sr. Global Product Manager, Masterflex Bioprocessing, USA.
Besides requiring precise liquid metering, dosing and transfer, virtually all pharmaceutical and biotechnology research, development and production processes demand sterility, fluid isolation and zero contamination potential to assure a high level of process and product security. The FDA also has significant concerns regarding contamination, including cross contamination of biotech products that could potentially alter the safety, identity, strength, quality or purity of the product. Validation cleaning processes are required and often time-consuming and costly.
Solution
Sterile liquid flow is paramount in pharmaceutical and bioprocessing applications, which is why Masterflex peristaltic pumps are highly-suited for these demanding processes. Whether it be pharmaceutical products, live cell cultures, nutrients or bioreactor constituents, our validation-friendly, non-contaminating peristaltic pump systems are designed to ensure precise, sterile control and management of flow while providing longer process run periods and reduced downtime – all which translates to process optimization.
Benefits
One major reason Masterflex peristaltic pump systems are ideal for facilitating aseptic and sterile processes is because, unlike rotary lobe, centrifugal and other pump designs, Masterflex pumps have no check valves, seals, diaphragms or other components in the fluid stream – the fluid does not come into contact with the pump itself, only inside sterile tubing. The result: fluid isolation – a completely closed system for contamination- free aseptic/sterile flow at a wide range of flow rates, making applications easy to clean and maintain. Maintaining the integrity of high purity liquid flows is essential in pharmaceutical and biopharmaceutical applications. Whether it be in research, clinical development, full scale production, or contract manufacturing, problems associated with instrument contamination can be very costly. In these processes, the control and management of high purity flow must rely on pumping systems that provide sterility and precision at all times.
Clean pump technology
Masterflex peristaltic pumps employ clean pump technology to provide a totally closed system for contamination-free aseptic/sterile flow. Cleaning the pump internals is never required because flows come in contact with only the inside of one uninterrupted length of silicone or special grade tubing that will withstand repeated sterilization. CIP/SIP (cleaning/sterilization in place) is easy. With a Masterflex Easy-Load® pump head, for example, the tubing can be sterilized in place after simply releasing compression on the roller. Rather than sterilize the tubing, another option is to treat the tubing as a disposable material and simply replace it when the process is completed. This can simplify cleaning validation, reduce the risk of contamination by personnel, cut costs and speed up the process – an especially viable option in this era when pressure is mounting to reduce validation costs while increasing compliance with cGMP. Treating tubing as a disposable or single-use material can also be particularly useful for contract manufacturers, or in clinical phases of development, when a facility may handle a variety of drugs
Sterility, fluid isolation, zero contamination
Masterflex pumps provide a completely closed system for contamination-free aseptic/sterile flow control.
With adjustable 650:1 resolution, bi-directional flow and self-priming capabilities, Masterflex pumps provide for smooth, seamless operation.
Masterflex pumps provide for sterile, precision liquid metering, dosing and transfer, with an accuracy of ± 0.5% or better, flow rates from 0.006 mL/min to 33.000 mL/min, and repeatability of 99.5 percent.
Very gentle method of pumping does not damage shear-sensitive products, such as cell cultures.
Masterflex pumps are extremely flexible with product viscosities.
Masterflex pumps are CIP/SIP capable.
Positive shutoff helps ensure precise metering, dosing and transfer while providing a high degree of process and product security.
Masterflex pumps are powerful and compact, making them a perfect fit for clean room applications.
Because Masterflex pumps are nearly 100 percent volumetrically efficient, very little heat is introduced into the process, compared to rotary lobe and centrifugal pumps.
A wide range of superior tubing material is available for most any application.
Peristaltic design means no valves, glands or seals to wear out or become clogged.
Requires very little maintenance to keep in peak operating condition.
Pharmaceutical/ BioPharmaceutical high purity solutions
Some applications for Masterflex pumps include:
Filling and dispensing
Processing of fermentation products
Cell propagation Biomass separation
Ultra filtration processes
Aspiration of tissue culture medium
Bioprocess container transfer
Circulation of cell suspension in fermentation
Dispensing into petri dishes
Harvesting cell media nutrient supply for cultures